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Hypersensitivity pneumonitis
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Hypersensitivity pneumonitis

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Extrinsic allergic alveolitis; Farmer's lung; Mushroom picker's disease; Humidifier or air-conditioner lung; Bird breeder's or bird fancier's lung

Hypersensitivity pneumonitis is inflammation of the lungs due to breathing in a foreign substance, usually certain types of dust, fungus, or molds.

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  • Causes

    Hypersensitivity pneumonitis usually occurs in people who work in places where there are high levels of organic dusts, fungus, or molds.

    Long-term exposure can lead to lung inflammation and acute lung disease. Over time, the acute condition turns into long-lasting (chronic) lung disease.

    Hypersensitivity pneumonitis may also be caused by fungi or bacteria in humidifiers, heating systems, and air conditioners found in homes and offices. Exposure to certain chemicals, such as isocyanates or acid anhydrides, can also lead to hypersensitivity pneumonitis.

    Examples of hypersensitivity pneumonitis include:

    Bird fancier's lung: This is the most common type of hypersensitivity pneumonitis. It is caused by repeated or intense exposure to proteins found in the feathers or droppings of many species of birds.

    Farmer's lung: This type of  hypersensitivity pneumonitis is caused by exposure to dust from moldy hay, straw, and grain.

  • Symptoms

    Symptoms of acute hypersensitivity pneumonitis often occur 4 to 6 hours after you have left the area where the offending substance is found. This makes it difficult to find a connection between your activity and the disease. Symptoms might resolve before you go back to the area where you encountered the substance.

    Symptoms may include:

    • Chills
    • Cough
    • Fever
    • Malaise (feeling ill)
    • Shortness of breath

    Symptoms of chronic hypersensitivity pneumonitis may include:

    • Breathlessness, especially with activity
    • Cough, often dry
    • Loss of appetite
    • Unintentional weight loss
  • Exams and Tests

    Your doctor may hear abnormal lung sounds called crackles (rales) when listening to your chest with a stethoscope.

    Lung changes due to chronic hypersensitivity pneumonitis may be seen on a chest x-ray. Other tests may include:

    • Aspergillus precipitin test
    • Bronchoscopy with washings, biopsy, and bronchoalveolar lavage
    • CBC
    • High-resolution CT scan of the chest
    • Hypersensitivity pneumonitis antibody panels
    • Krebs von den Lungen-6 assay (KL-6)
    • Pulmonary function tests
    • Surgical lung biopsy
  • Treatment

    First, the offending substance must be identified. Treatment involves avoiding this substance in the future. Some people may need to change jobs if they cannot avoid the substance at work.

    If you have a chronic form of this disease, your doctor may recommend that you take glucocorticoids (anti-inflammatory medicines). Sometimes treatments used for asthma can help people with hypersensitivity pneumonitis.

  • Outlook (Prognosis)

    Most symptoms go away when you avoid or limit your exposure to the material that caused the problem.

  • Possible Complications

    The chronic form of this disease may lead to pulmonary fibrosis. This is a scarring of the lung tissue that often is not reversible. Eventually, end-stage lung disease and respiratory failure can occur.

  • When to Contact a Medical Professional

    Call your health care provider if you develop symptoms of hypersensitivity pneumonitis.

  • Prevention

    The chronic form can be prevented by avoiding the material that causes the lung inflammation.

Related Information

  AllergenLung diseaseChest x-rayInterstitial lung ...   Interstitial lung ...  

References

Rose CS, Lara AR. Hypersensitivity pneumonia. In: Mason RJ, Broaddus VC, Martin TR, et al., eds. Murray and Nadel's Textbook of Respiratory Medicine. 5th ed. Philadelphia, Pa: Elsevier Saunders; 2010:chap 66.

Tarlo SM. Occupational lung disease. In: Goldman L, Schafer AI, eds. Goldman’s Cecil Medicine. 24th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 93.

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Review Date: 5/30/2013  

Reviewed By: Denis Hadjiliadis, MD, Assistant Professor of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

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