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Eosinophilic fasciitis
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Eosinophilic fasciitis

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Eosinophilic fasciitis is a very rate syndrome in which muscle tissue under the skin, called fascia, becomes swollen and thick. The hands, arms, legs, and feet can swell quickly.

The disease may look similar to scleroderma but is not related.

The cause of eosinophilic fasciitis is unknown. In people with this condition, white blood cells called eosinophils, build up in the muscles and tissues. Eosinophils are linked to allergic reactions. The syndrome is more common in people ages 30 to 60.

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  • Causes

    The cause of eosinophilic fasciitis is unknown. In people with this condition, white blood cells called eosinophils, build up in the muscles and tissues. Eosinophils are linked to allergic reactions. The syndrome is more common in people ages 30 to 60.

  • Symptoms

    • Bone pain or tenderness
    • Carpal tunnel syndrome
    • Muscle weakness
    • Tenderness and swelling of the arms, legs and sometimes the joints
    • Thickened skin that looks puckered
  • Exams and Tests

    Tests that may be done include:

    • Gamma globulins (a type of immune system cell)
    • Erythrocyte sedimentation rate (ESR)
    • MRI
    • Muscle biopsy
    • Skin biopsy
  • Treatment

    Corticosteroids and other immune-suppressing medicines are used to relieve symptoms. These medicines are more effective when started  early in the disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) may also help reduce symptoms.

  • Outlook (Prognosis)

    In most cases, the condition goes away within 3 to 5 years. However, symptoms may last longer or come back.

  • Possible Complications

    Arthritis is a rare complication of eosinophilic fasciitis. Some people may develop very serious blood disorders or blood-related cancers, such as aplastic anemia or leukemia. The outlook is much worse if blood diseases occur.

  • When to Contact a Medical Professional

    Call your health care provider if you have symptoms of this disorder.

  • Prevention

    There is no known prevention.

Related Information

  Eosinophil count -...    

References

Lee LA, Werth VP. The Skin and Rhematic Diseases. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, Pa: Saunders Elsevier;2012:chap 43.

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Review Date: 3/22/2013  

Reviewed By: Ariel D. Teitel, MD, MBA, Clinical Associate Professor of Medicine, NYU Langone Medical Center. Review provided by VeriMed Healthcare Network. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

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