/SiteAssets/Images/FMOLHSBlankBanner.png

Health Information

Autosomal dominant
Bookmarks

Autosomal dominant

Print-Friendly  

Inheritance - autosomal dominant; Genetics - autosomal dominant

Autosomal dominant is one of several ways that a trait or disorder can be passed down (inherited) through families.

In an autosomal dominant disease, if you inherit the abnormal gene from only one parent, you can get the disease. Often, one of the parents may also have the disease.

I Would Like to Learn About:

  • Information

    Inheriting a disease, condition, or trait depends on the type of chromosome affected (autosomal or sex chromosome). It also depends on whether the trait is dominant or recessive.

    A single abnormal gene on one of the first 22 nonsex (autosomal) chromosomes from either parent can cause an autosomal disorder.

    Dominant inheritance means an abnormal gene from one parent can cause disease, even though the matching gene from the other parent is normal. The abnormal gene dominates.

    An autosomal dominant disease can also occur as a new condition in a child when neither parent has the abnormal gene.

    A parent with an autosomal dominant condition has a 50% chance of having a child with the condition. This is true for each pregnancy. It means that each child's risk for the disease does not depend on whether their sibling has the disease. Children who do not inherit the abnormal gene will not develop or pass on the disease.

    If someone is diagnosed with an autosomal dominant disease, that person's parents should also be tested for the abnormal gene.

    Examples of autosomal dominant disorders include Huntington's disease and neurofibromatosis type 1.

Related Information

  GenesChromosomeGenetics    

References

Stankiewicz P, Lupsik JR. Gene, genomic, and chromosomal disorders. In: Goldman L, Ausiello D, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 40.

BACK TO TOP 

Review Date: 5/5/2014  

Reviewed By: Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

adam.com

 
A.D.A.M. content is best viewed in IE9 or above, Fire Fox and Google Chrome browser.