AERD is linked to atherosclerosis. Atherosclerosis is a common disorder of the arteries. It occurs when fat, cholesterol, and other substances build up in the walls of arteries and form a hard substance called plaque.
In AERD, cholesterol crystals break off from the plaque lining the arteries. These crystals move into the bloodstream. Once in circulation, the crystals get stuck in tiny blood vessels called arterioles. There, they reduce blood flow to tissues and cause swelling (inflammation) and tissue damage that can harm the kidneys or other parts of the body
The kidneys are involved about half of the time. Other body parts that may be involved include the skin, eyes, muscles and bones, brain and nerves, and organs in the abdomen. Acute kidney failure is possible if the blockages of the kidney blood vessels are severe.
Atherosclerosis of the aorta is the most common cause of AERD. The cholesterol crystals may also break off during aortic angiography, cardiac catheterization or surgery of the aorta or other major arteries.
In some cases, AERD may occur without a known cause.
The risk factors for AERD are the same as risk factors for atherosclerosis, including age, male gender, cigarette smoking, high blood pressure, and diabetes.