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Antithyroid microsomal antibody
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Antithyroid microsomal antibody

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Thyroid antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Thyroid peroxidase antibody; TPOAb

Antithyroid microsomal antibody is a test to measure antithyroid microsomal antibodies in the blood. Microsomes are found inside thyroid cells. The body produces antibodies to microsomes when there has been damage to thyroid cells.

I Would Like to Learn About:

  • How the Test is Performed

    A blood sample is needed.

  • How the Test will Feel

    When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

  • Why the Test is Performed

    This test is done to confirm the cause of thyroid problems, including Hashimoto thyroiditis.

    The test is also used to find out if an immune or autoimmune disorder is damaging the thyroid.

  • Normal Results

    A negative test is normal.

    Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your doctor about the meaning of your specific test results.

  • What Abnormal Results Mean

    A positive test may be due to:

    • Granulomatous thyroiditis
    • Hashimoto thyroiditis

    High levels of these antibodies have also been linked to an increased risk of:

    • Miscarriage
    • Preeclampsia
    • Premature birth
    • In vitro fertilization failure

    A positive result does not always mean that you need treatment for your thyroid. But it may mean that you have a chance of developing thyroid disease in the future.

    Anti-microsomal antibodies may be seen in your blood if you have other autoimmune conditions, including:

    • Autoimmune hemolytic anemia
    • Autoimmune hepatitis
    • Rheumatoid arthritis
    • Sjögren syndrome
    • Systemic lupus erythematosus 
  • Risks

    Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

    Other risks associated with having blood drawn are slight but may include:

    • Excessive bleeding
    • Fainting or feeling light-headed
    • Hematoma (blood accumulating under the skin)
    • Infection (a slight risk any time the skin is broken)

Related Information

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References

Guber HA, Faraq AF. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 24.

Salvatore D, Davies TF, Schlumberger MJ, et al. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, Larsen PR, et al, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 11.

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Review Date: 5/10/2014  

Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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